LL-37 5mg
LL-37 is a human antimicrobial peptide known for its broad-spectrum activity against bacteria, viruses, and fungi, as well as its powerful role in immune regulation and wound healing. A naturally occurring peptide fragment of the cathelicidin family, LL-37 has been widely studied for its applications in skin regeneration, chronic infections, and inflammatory disorders. It is ideal for research related to innate immunity and tissue repair.
LL-37 is a human antimicrobial peptide known for its broad-spectrum activity against bacteria, viruses, and fungi, as well as its powerful role in immune regulation and wound healing. A naturally occurring peptide fragment of the cathelicidin family, LL-37 has been widely studied for its applications in skin regeneration, chronic infections, and inflammatory disorders. It is ideal for research related to innate immunity and tissue repair.
LL-37 is a human antimicrobial peptide known for its broad-spectrum activity against bacteria, viruses, and fungi, as well as its powerful role in immune regulation and wound healing. A naturally occurring peptide fragment of the cathelicidin family, LL-37 has been widely studied for its applications in skin regeneration, chronic infections, and inflammatory disorders. It is ideal for research related to innate immunity and tissue repair.
LL-37 is the only known human cathelicidin and is derived from the precursor protein hCAP18. It plays a central role in the body’s first line of defense by targeting invading pathogens and modulating the immune response. Unlike conventional antibiotics, LL-37 exhibits immunomodulatory activity, helping balance inflammation while promoting wound closure and tissue regeneration.
Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabled as a drug, food or cosmetic.
What is LL-37?
LL-37 is a cationic peptide composed of 37 amino acids, beginning with two leucines—hence the name. It is produced by epithelial cells, immune cells (like neutrophils), and in response to vitamin D stimulation. In addition to its antimicrobial effects, LL-37 facilitates cell migration, angiogenesis, and the resolution of inflammation, making it a multifaceted peptide in both innate immunity and regenerative research.
Key Functions and Benefits
Antimicrobial Activity: Exhibits broad-spectrum action against bacteria, viruses, and fungi.
Wound Healing: Promotes re-epithelialization, angiogenesis, and collagen remodeling.
Immune Modulation: Regulates cytokine release and inflammatory signaling pathways.
Biofilm Disruption: Breaks down microbial biofilms, aiding in treatment-resistant infections.
Skin Health: Studied for its role in treating chronic wounds, psoriasis, and acne.
Mechanisms of Action
LL-37 disrupts microbial membranes through electrostatic interactions, leading to cell lysis. Beyond its antimicrobial properties, it binds to various cell receptors (including FPR2 and EGFR), triggering downstream effects such as chemotaxis, immune cell activation, and tissue regeneration. It also modulates the expression of pro- and anti-inflammatory cytokines, helping to resolve inflammation without suppressing immune defense.
Unique Characteristics
LL-37 is one of the few peptides that combine direct antimicrobial action with immune system modulation and regenerative support. Its ability to stimulate healing while minimizing infection risk has made it a focus of research in dermatology, wound care, and chronic inflammatory diseases.
LL-37 Peptide Structure
Source: PubChem
Sequence: Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
Molecular Formula: C205H340N60O53
Molecular Weight: 4493 g/mol
PubChem CID: 16198951
vCAS Number: 154947-66-7
Synonyms:
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
